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Welcome to the Made In Weizmann Portal A single entry point for Databases, FTP Servers, On-line Data Processing engines and Software designed and developed at the Weizmann Institute of Science, Rehovot, Israel. |
26th January 2011 
Schmidt Lecture Hall |
Ligand-Protein Contacts & Contacts of Structural Units
With this server you can discover if your protein might have an unusally large net charge or dipole moment, and how this might relate to specific structural features of the protein, and thereby its function.
Analysis of correlated mutations
The program PARE calculates the change in rate of association (kon) of mutant protein-protein interaction complexes from the change in the Debye Huckel energy of interaction between proteins using transition state theory. As input, the pdb coordinates of the complex are required. For calculating absolute rates, one has to add the value of kon of the wild-type complex as well.
The F2CS server provides access to the software, F2CS2.00, that implements an automated prediction server of SCOP's class and fold classifications and CATH's class, architechture and topology classifications for any protein that appears in the latest version of the FSSP database (Getz et al., Proteins (2002) 46, 405). The prediction is based on the FSSP Z-scores.
The CTWC server provides access to the software, CTWC1.00, that implements Coupled Two Way Clustering [Getz et al., PNAS (2000), 97, 12079], a method designed to mine gene expression data. The user uploads the expression matrix and, optionally, a table of labels for samples and one for genes. CTWC clusters groups of samples, using their expression over groups of genes, and vice versa.
A tool for sequence identification, analysis, characterization and annotation. This server will try to find relevant information related to your sequence.
Will this protein fold? This dynamic interactive process estimates the local and general probability, based on algorithm proposed by Uversky VN, Gillespie JR, and Fink AL. Why are 'natively unfolded' proteins unstructured under physiologic conditions? Proteins 2000; 41:415-427.
The Motif Analysis Workbench is a WWW interface for automated comprehensive analyses of promoter regulatory motifs and the effect they exert on mRNA expression profiles.
A program to map oligopurine.oligopyrimidine and other binary DNA tracts. Also, a short one line description for each gene in a chromosome.
BestPrimers(c) provides a simple interface for primers calculation, with FoldIndex(c) support.
SeqAlert(c) is a sequence alerting service that will periodically compare your sequence(s) against sequences from determined 3D structures, or structures being determined at PDB and TargetDB, the database of target sequences from worldwide structural genomics projects.
RecentReferences will try to find recent publications related to your DNA or protein sequence.
Prediction of side chain conformations and mutations on fixed backbone
Analysis of two spheres of contacting residues around ligands (using LPC and CSU)
Given a PDB structure of an unbound protein ProMate predicts the location of a potential binding site where transient interaction with another protein may occur.
Suggest an Expression System based on a provided sequence. How: suggestES takes the protein sequence you provide and scans a large database with protein sequences with known results for different expression systems.
verifyCloning compares your source data with one or more results from DNA sequencing.
HyPare is a newly designed tool based on the PARE algorithm (Predicting Association Rate Enhancement). With HyPare you can find hotspots for association, and thus, engineer your proteins for faster and tighter binding.
NUMODs (nuclease-associated modular DNA-binding domains) can be found, in addition to a service that locates NUMODs on a given protein/DNA sequence. NUMODs are new types of short conserved sequence domains in homing endonucleases and related proteins. These domains are modular, appearing in various combinations. One domain includes a motif known by structure as a novel sequence-specific DNA-binding helix. Sequence similarity shows two other domains to be new types of HTH DNA-binding domains. We term the new domains nuclease-associated modular DNA-binding domains (NUMODs).
Enables the identification of active sites in enzymes based on the analysis of protein structures as networks of interactions between amino acids. The network property of closeness describes the average shortest path of each residue in a given protein structure from all other residues within the structure. The combination of high closeness values and relative surface area of each residue enables to predict its likelihood of being an active site residue. The optimal values of closeness and relative surface area were derived from a thorough examination of 178 protein structures with well annotated active sites (Bartlett GJ. et al. J Mol Biol. 2002 Nov 15;324(1):105-21).
The program determines which of all possible peptide nonamers from a protein sequence adheres to a mouse MHC class-II molecule. All motifs used are experimentally derived.
a PROTeins MOTif analysis tool. This web site analyzes structure of proteins and output the list of hydrogen bonding patterns network motifs.
AquaProt analyses protein-protein binding interface, defines inter-residue interaction map within the interface and extracts related water molecules.
Hunter is a knowledge-based potential for protein structure modeling and evaluation. It is based on a novel 4-distance description of side chain interactions. This web site interactively presents Jmol visualization depicting preferred orientation of two residues in 3D and 2D space, a tool predict side chain conformations and changes in protein stability and binding affinity upon mutation.
Plant hormones play a pivotal role in plant growth and physiology. HORMONOMETER is a tool for evaluating any Arabidopsis transcriptome response through the perspective of similar events that happen upon direct hormonal activation. This tool applies vector-base analysis to rapidly compare lists of user supplied transcripts activity based on microarray to a database of hormone transcript profiles yielding correlation values and a color coded heat map.
(Nucleotide Identity Comparisons for Evolution and Recombination) allows evaluation of the quality of inferred phylogenies (evolutionary trees).
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